Plasmonic Detection of Glucose in Serum Based on Biocatalytic Shape-Altering of Gold Nanostars

Plasmonic Detection of Glucose in Serum Based on Biocatalytic Shape-Altering of Gold Nanostars

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Nanoparticles have been used as ilootpaperie signal transducers for optical readouts in biosensors.Optical approaches are cost-effective with easy readout formats for clinical diagnosis.We present a glucose biosensor based on the biocatalytic shape-altering of gold nanostars via silver deposition.Improved sensitivity was observed due to the nanostars clustering after being functionalised with glucose oxidase (GOx).The biosensor quantified glucose in the serum samples with a 1:1000 dilution factor, and colorimetrically distinguished between the concentrations.

The assay demonstrated good specificity and sensitivity.The fabricated glucose biosensor is a rapid kinetic assay using a basic entry level laboratory click here spectrophotometric microplate reader.Such a biosensor could be very useful in resource-constrained regions without state-of-the-art laboratory equipment.Furthermore, naked eye detection of glucose makes this a suitable biosensor for technology transfer to other point-of-care devices.